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CBD & Depression

CBD & Depression

DEPRESSION is the emotional feeling of low spirits, sadness and loss of hope.  It is something all of us experience at one time or another and in most cases, it is mild and does not warrant any form of treatment aside from rest or talking to someone about your worries.   However, in some cases, this feeling may develop into something that never seems to go away.  Depression can be caused by a combination of serious environmental and psychological factors or the predisposition may be passed from parents to children through genes.

It is estimated that about 14.8 million of the adults in the U.S experience depression in a given year.  Women are 70% more likely to suffer from major depression than men.  Additionally, it is estimated that 3.3% of 13- to 18-year-olds have suffered from a debilitating depressive attack.

There are several depression symptoms, and not everyone will have the same ones.  Aside from the feeling of low spirits, hopelessness and sadness, other symptoms that can help you tell if you or someone you know are depressed: Here is a list of the most common symptoms:

  • A feeling of worthlessness or guilt
  • Inability to fall asleep
  • Feeling extremely sad and negative
  • Significant changes in appetite; either eating too much or too little
  • Either sleeping too much or having difficulties sleeping
  • Noticeable loss of energy or obvious instances of fatigue
  • No longer taking pleasure in things you used to enjoy
  • An inability to concentrate, think or make decisions
  • Thoughts of death and suicide

Medical professionals assert that a person must display at least five of the above symptoms for at least two weeks to be diagnosed with depression.

In the U.S, major depression is among the most common psychological disorders. Although there are several forms of depression including:

  • Major depression
  • Bipolar depression
  • Chronic depression
  • Psychotic depression
  • Seasonal Affective Disorder (Also known as SAD or seasonal depression)
  • Postpartum depression
  • Substance-induced mood disorder (SIMD)

The World Health Organization predicts that unipolar depression “will be the second most prevalent cause of illness-induced disability by the year 2020” and antidepressants are the third most common psychiatric drugs prescribed worldwide.



It appears that CBD may be an extremely effective and fast acting antidepressant.  You should discuss the use of CBD for depression with your medial practitioner or health care professional.

There are many products on the market meant to treat both mild and chronic depression.  Most of these, usually referred to as antidepressants, act by changing how the body’s hormones affect the activity of the brain and, therefore, the way you feel.

CBD oil may be a safe, effective and almost instantaneous alternative.  Pharmaceutical drugs can take weeks, if not months, before the patient notices a difference and oftentimes antidepressant medications are extremely addictive with a long list of potential side effects if you quit taking them suddenly. The worst part is that antidepressants only work for some people (1 in 3 people with depression are unable to find relief through current antidepressant drugs).

It is common for patients to experience withdrawal symptoms such as dizziness, headache, nausea and even hallucinations when they stop taking the pharmaceuticals.  If you currently use any pharmaceutical or other medications for your depression is important that your doctor advises you on how to go about changing from the chemical substances to CBD



A number of OBX mice (surgically modified as a stand-in for tests with depression meds) were recently tested. The results showed a near instant improvement in mice that were treated with CBD.  Observing the mice 30 minutes after treatment with CBD displayed a noticeable decrease in hyperactivity.  Which is a distinct symptom of hyperactivity as well as depression in humans.

Studies are now showing CBD interacts significantly with the 5-HT1A neuro-receptor.  This receptor typically binds to and reuptakes serotonin into the neurons in various parts of the brain reducing amounts of free serotonin in the extracellular space.  Serotonin is a neurotransmitter known to be key in the treatment of depression, thus any compound, such as selective serotonin reuptake inhibitors (SSRI’s) or Cannabidiol, which increase levels of serotonin are thought to be ideal in the treatment of depression and are thought to have little or no side effects.


Suggested Use:

Multiple articles recommend a dose of 25mg to 50mg a day may be effective in all types of Depression.  It is also suggested that you try increasing dosage every 3-4 weeks by 25mg until symptom relief and to decrease amount of CBD with any worsening of symptoms.

It’s important to understand that CBD oil is not a miracle cure.  The effects of CBD oil are not instant.  CBD may take some time to work, so it is important to find the right dosage.


For Depression: 25 mg CBD by mouth twice a day:

GLNH Soft Gels (10mg): 2-3 gels twice a day

GLNH Gummies (10mg); 2-3 gummies twice a day

GLNH 350 mg tincture: 2 droppers – 4 droppers twice a day

GLNH 500 mg tincture: 2 droppers – 3 droppers twice a day

GLNH Suppositories (500mg): 1 suppository daily

GLNH Vaporizer (500mg): 2-5 puffs twice a day