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CBD & Drug Interactions

Cannabidiol (CBD) can inhibit the cytochrome P-450 system’s ability to metabolize certain drugs, the cytochrome P-450 enzyme system is a system that contains over 50 enzymes that process and eliminate toxins within the liver that is responsible for metabolizing 90 percent of the drugs you consume.  If it is compromised, it can lead to an overall increase in the drug processing times.  This leads to higher levels of the drug in your system at one time, which can cause unwanted side effects and even overdose.  Thus, if you are taking a drug affected by CBD, you may need a dosage adjustment in order to take both drugs safely.

Any drug metabolized by cytochrome P-450 enzymes could potentially interact with cannabidiol. Drugs known to use the cytochrome P-450 system include:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Anti-arrhythmics
  • Antibiotics
  • Anesthetics
  • Anti-psychotics
  • Anti-depressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs
  • Angiotension II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

This list does not necessarily contain every medication that could be affected by CBD. Likewise, not every medication in each of the categories listed will cause an interaction.  For this reason, you should consult with a medical professional before taking any combination of drugs at the same time, as alternative medications or dosage adjustments may be required.